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Are antidepressants spermicidal?

You might think so looking at newspaper reports of a study examining the effect of paroxetine on sperm quality. It’s well known that antidepressants, the SSRIs in particular, can have sexual side...

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St John’s wort works for depression…in Germany

The benefits of St John’s wort (SJW) have been widely reported this week following the publication of this study. It’s not, as some articles suggest, a new trial but actually an update of a Cochrane...

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A Gorilla in the Mist

Trying to find evidence to guide practice in mental health can be perplexing at the best of times. Take antidepressants for example: seemingly prescribed by the bucketload (170 million prescriptions...

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A drug watchdog shows its fangs…at last

That drug companies play fast and loose with study data is hardly news. It’s a widely-acknowledged problem that has been highlighted particularly with antidepressant trials where the advantage over...

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Those unknown unknowns: the importance of publication bias

Can you believe what you read in a medical journal? Probably not, as many if not most research findings turn out to be false. Poor research design and underpowered studies are part of the problem but...

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Freakonomic Mental Health

More antidepressants please…and bump up the Ritalin too. That seems to be the suggestion from this study published by the National Bureau of Economic Research in the US, making a link between new drug...

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Right to a fair trial: St John’s wort

The updated NICE guideline for depression is just out. Here is what it has to say about St John’s wort: Although there is evidence that St John’s wort may be of benefit in mild or moderate depression,...

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